pH of the Skin: Issues and Challenges

Karger

Access this book content in full by logging in

Not yet a member? Sign up to access the full book.
iPhone placeholder
pH of the Skin: Issues and Challenges

This book has been converted and optimized for reading, search and navigation on smartphones by Indextra AB.

The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research.

Reports on results of pH measurements from living skin established the term 'acid mantle' - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is, therefore, no surprise that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and 'correct' skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity.

Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data.

In this volume (No54 in the 'Current Problems in Dermatology' series) we present a unique collection of 21 papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.

Editors: Christian Surber, Christoph Abels, and Howard Maibach

Knowledge at hand

Make treatment decisions with confidence by always having the essential medical resources at hand.

Indextra gives you access to 750+ medical books including the Oxford Handbooks and Oxford Specialist Handbooks, Stahl’s and Maudsley as well as the NICE guidelines, BNF and BNF-C, ICD-10, TNM and much more.


Our app
Indextra

In order for the Indextra site to work as expected you need to update your browser.

Update